St. Joe's baseball has had a long and successful history. In the 1950's, St. Joe's captured several Georgetown Cups under legendary Coach Frank Schiavone. One of the top pitchers in the area during this time was Frank Kreutzer, who went on to pitch in the major leagues for 6 years.

Past Athletic Director Joe Wolf '57 took over in 1964 and captured back-to-back Georgetown Cups and League Championships in 1968 and 1969. Hall of Fame players Mike Cahill, Dennis Murphy, Gary Castine and Joe Scaffidi were the leaders of these teams, along with current head coach Rick Mariano. St. Joe's captured their next cup in 1979 under Coach Ron Leib. Hall of Famer Chris Rehbaum, who was drafted in the 1st round by the Cleveland Indians, was the star player on that team, along with Jim Lindner and Peter Hammerl.

In the mid 80's, former Detroit Tiger minor league pitcher Jim Tuholski '58 took over. His team was led by Tom Tuholski, who played several years in the Pittsburgh Pirates organization, Hall of Famer Marty Hurley, and present day varsity coach Paul Nasca '86. The St Joe's baseball team captured the Georgetown Cup again in 1991 under Coach Tuholski. This team was led by 1st Team All-Catholic player P.J. Amodeo.

Coach Rick Mariano took over the reins in 1997. Under his leadership, the program continued to perform at the highest level capturing back-to-back Georgetown Cups and League Championships in 1998 and 1999, as well as being ranked the #1 Team in WNY. All-WNY players Rick Mariano Jr., Kevin Eberz, and Mike Ferguson, who was the winning pitcher in both Cup finals, led the team. They recently repeated the duplicate feat of winning both the League and Georgetown Cup Championships in 2005.

During Coach Mariano's tenure, his team's captured four league championships and were in the Georgetown Cup Finals six times in twelve years. First Team All-WNY players Mike Bloom, Lee Keysor, Justin Niefer, Mike Mariano and Joe Mariano were all key contributors to those teams. Coach Mariano's teams have sent over 40 players on to college baseball during the past 14 years. Coach Mariano was honored by the St. Joe's Alumni Association when he was elected to the St. Joe's Hall of Fame in 2009.  Coach Mariano retired following the 2010 season with seven regular season titles, three Georgetown Cups and a .680 winning percentage under his belt.

Current Coach Paul Nasca '86 played at St. Joe's under Coach Tuholski where he received All-Catholic and All-WNY honors.  Following his stellar career at St. Joe's, Coach Nasca continued his baseball prowess at Canisius College where he earned All-Conference honors in the MAAC.  Coach Nasca is the fourth brother to have graduated from St. Joe's and is the younger brother of St. Joe's Sports Hall of Famer Mark Nasca '77. (David '75 and Steven '73)  Coach Nasca recorded a 14-11 record in his first year at the helm.